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Lutsenko Lab
Home
Research
Publications
Members
Lab News
Former Members
Contact Us
Home
Research
Publications
Members
Lab News
Former Members
Contact Us
 

Department of Physiology
Johns Hopkins University School of Medicine

725 N. Wolfe Street
203 Hunterian
Baltimore, MD 21205

  • Mechanism of Cu entry into the brain: many unanswered questions.

    Roy S, Lutsenko S. Neural Regen Res. 2024 Nov 1;19(11):2421-2429. doi: 10.4103/1673-5374.393107. Epub 2024 Jan 8. PMID: 38526278; PMCID: PMC11090436.

  • Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard.

    Murata D, Roy S, Lutsenko S, Iijima M, Sesaki H. Dev Cell. 2024 Jul 3:S1534-5807(24)00386-1. doi: 10.1016/j.devcel.2024.06.008. Epub ahead of print. PMID: 38986607.

  • α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance.

    Ekaterina Kabin, Yixuan Dong, Shubhrajit Roy, Julia Smirnova, Joshua W. Smith, Martina Ralle, Kelly Summers, Haojun Yang, Som Dev, Yu Wang, Benjamin Devenney, Robert N. Cole, Peep Palumaa, and Svetlana Lutsenko.ATP7A-dependent copper sequestration contributes to termination of b-CATENIN signaling during early adipogenesis

    H. Yang1,**E. Kabin, Y. Dong, X. Zhang, M. Ralle, S. Lutsenko* 10.1016/j.molmet.2024.101872

  • Mechanism of Cu entry into the brain: many unanswered questions

    Roy, Shubhrajit*; Lutsenko, Svetlana 10.4103/1673-5374.393107

  • α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance.

    Ekaterina Kabin, Yixuan Dong, Shubhrajit Roy, Julia Smirnova, Joshua W. Smith, Martina Ralle, Kelly Summers, Haojun Yang, Som Dev, Yu Wang, Benjamin Devenney, Robert N. Cole, Peep Palumaa, and Svetlana Lutsenko. 10.1073/pnas.2305961120

  • Atp7b-dependent choroid plexus dysfunction Causes transient copper deficit and metabolic changes in the developing mouse brain.

    Clorissa L Washington-Hughes, Shubhrajit Roy, Herana Kamal Seneviratne, Senthilkumar S Karuppagounder, Yulemni Morel, Jace W Jones, Alex Zak, Tong Xiao, Tatiana N Boronina, Robert N Cole, Namandjé N Bumpus, Christopher J Chang, Ted M Dawson, Svetlana Lutsenko. PLoS Genet. 2023 Jan 10;19(1):e1010558. doi: 10.1371/journal.pgen.1010558

  • Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner.

    Courtney J. McCann, Nesrin M. Hasan, Teresita Padilla-Benavides, Shubhrajit Roy, Svetlana Lutsenko. Front. Mol. Biosci, 2022 Dec 5; https://doi.org/10.3389/fmolb.2022.1067490

  • Oxysterol misbalance critically contributes to Wilson disease pathogenesis.

    Som Dev, Abigael Mucheditsi, Aline Gottlieb, Pragney Deme, Sean Murphy, Kathleen L. Gabrielson, Yixuan Dong, Robert Hughes, Norman J. Haughey James P. Hamilton and Svetlana Lutsenko. Sci Adv. 2022 Oct 21; 8(42):eadc9022. doi: 10.1126/sciadv.adc9022.Epub 2022 Oct 19.

  • Copper induces cell death by targeting lipoylated TCA cycle protein.

    Peter Tsvetkov , Shannon Coy, Boryana Petrova, Margaret Dreishpoon, Ana Verma, Mai Abdusamad, Jordan Rossen, Lena Joesch-Cohen, Ranad Humeidi, Ryan D. Spangler, Jake Eaton, Evgeni Frenkel, Mustafa Kocak, Steven M. Corsello, Svetlana Lutsenko, Naama Kanarek, Sandro Santagata, Todd R. Golub. Science. 2022 Mar 18;375(6586):1254-1261. doi: 10.1126/science.abf0529.Epub 2022 Mar 17

  • Dynamic and cell-specific transport networks for intracellular copper ions.

    Lutsenko, S. J Cell Sci. 2021 Nov 1;134(21):jcs240523. doi: 10.1242/jcs.240523.

  • Hepatic steatosis in the mouse model of Wilson Disease coincides with a muted inflammatory response.

    Gottlieb A, Dev S, DeVine L, Gabrielson KL, Cole RN, Hamilton JP, Lutsenko S.Am J Pathol. 2021 Oct 7:S0002-9440(21)00435-1. doi: 10.1016/j.ajpath.2021.09.010 

  • Systemic deletion of Atp7b modifies the hepatocytes' response to copper overload in the mouse models of Wilson disease.

    Muchenditsi A, Talbot CC Jr, Gottlieb A, Yang H, Kang B, Boronina T, Cole R, Wang L, Dev S, Hamilton JP, Lutsenko S.Sci Rep. 2021 Mar 11;11(1):5659. doi: 10.1038/s41598-021-84894-3.

  • Wilson disease

    Anna Członkowska , Tomasz Litwin , Petr Dusek , Peter Ferenci , Svetlana Lutsenko , Valentina Medici , Janusz K Rybakowski , Karl Heinz Weiss , Michael L Schilsky .Nat Rev Dis Primers. 2018 Sep 6;4(1):21. doi: 10.1038/s41572-018-0018-3.

  • Human copper transporter ATP7B (Wilson disease protein) forms stable dimers in vitro and in cells.

    Samuel Jayakanthan , Lelita T Braiterman , Nesrin M Hasan , Vinzenz M Unger , Svetlana Lutsenko . J Biol Chem. 2017 Nov 17;292(46):18760-18774doi: 10.1074/jbc.M117.807263.Epub 2017 Aug 24.