Welcome!
The Lutsenko Lab at Johns Hopkins University School of Medicine Department of Physiology is focused on the molecular mechanisms of copper homeostasis in normal and diseased cells.Copper is a fascinating biological metal that is indispensable for such fundamental processes such as respiration, myelination of neurons, biosynthesis of neurotransmitters, energy metabolism, pigmentation, iron transport, immune response, and many others. The role of copper as a cofactor of key metabolic enzymes has been well established. Recent studies uncovered additional roles for copper in cell differentiation, signaling, coordination of functions of intracellular compartments, and cell-to-cell communications.
Our laboratory investigates the new regulatory functions of copper. We use a broad spectrum of approaches, which include biochemical studies of molecules involved in copper transport and homeostasis, investigation of cellular processes regulated by copper using cell and tissue imaging, and the development and characterization of animal models for disorders or copper misbalance. If you are an independent thinker and like to explore new ideas, concepts, and methodology, we welcome you to the lab!
Recent Publications:
Ekaterina Kabin, Yixuan Dong, Shubhrajit Roy, Julia Smirnova, Joshua W. Smith, Martina Ralle, Kelly Summers, Haojun Yang, Som Dev, Yu Wang, Benjamin Devenney, Robert N. Cole, Peep Palumaa, and Svetlana Lutsenko.
Clorissa L Washington-Hughes, Shubhrajit Roy, Herana Kamal Seneviratne, Senthilkumar S Karuppagounder, Yulemni Morel, Jace W Jones, Alex Zak, Tong Xiao, Tatiana N Boronina, Robert N Cole, Namandjé N Bumpus, Christopher J Chang, Ted M Dawson, Svetlana Lutsenko. PLoS Genet. 2023 Jan 10;19(1):e1010558. doi: 10.1371/journal.pgen.1010558
Courtney J. McCann, Nesrin M. Hasan, Teresita Padilla-Benavides, Shubhrajit Roy, Svetlana Lutsenko. Front. Mol. Biosci, 2022 Dec 5; https://doi.org/10.3389/fmolb.2022.1067490
Oxysterol misbalance critically contributes to Wilson disease pathogenesis.
Som Dev, Abigael Mucheditsi, Aline Gottlieb, Pragney Deme, Sean Murphy, Kathleen L. Gabrielson, Yixuan Dong, Robert Hughes, Norman J. Haughey James P. Hamilton and Svetlana Lutsenko. Sci Adv. 2022 Oct 21; 8(42):eadc9022. doi: 10.1126/sciadv.adc9022.Epub 2022 Oct 19.
Copper induces cell death by targeting lipoylated TCA cycle protein.
Peter Tsvetkov , Shannon Coy, Boryana Petrova, Margaret Dreishpoon, Ana Verma, Mai Abdusamad, Jordan Rossen, Lena Joesch-Cohen, Ranad Humeidi, Ryan D. Spangler, Jake Eaton, Evgeni Frenkel, Mustafa Kocak, Steven M. Corsello, Svetlana Lutsenko, Naama Kanarek, Sandro Santagata, Todd R. Golub. Science. 2022 Mar 18;375(6586):1254-1261. doi: 10.1126/science.abf0529.Epub 2022 Mar 17
Dynamic and cell-specific transport networks for intracellular copper ions.
Lutsenko, S. J Cell Sci. 2021 Nov 1;134(21):jcs240523. doi: 10.1242/jcs.240523.
Hepatic steatosis in the mouse model of Wilson Disease coincides with a muted inflammatory response.
Gottlieb A, Dev S, DeVine L, Gabrielson KL, Cole RN, Hamilton JP, Lutsenko S.Am J Pathol. 2021 Oct 7:S0002-9440(21)00435-1. doi: 10.1016/j.ajpath.2021.09.010.
Muchenditsi A, Talbot CC Jr, Gottlieb A, Yang H, Kang B, Boronina T, Cole R, Wang L, Dev S, Hamilton JP, Lutsenko S.Sci Rep. 2021 Mar 11;11(1):5659. doi: 10.1038/s41598-021-84894-3.
Lab News:
Som presented at the Physiology department retreat 2022.
Som presents at the AASLD Liver Meeting 2021. Good job, Som!
Svetlana writes a review about cell-specific copper transport networks and contributes to a review connecting copper and cancer.
Kelly presents about X-ray Absorption Spectroscopy in Understanding and Treating Alzheimer's Disease. Watch it here.
Lab members participate in Physiology Department retreat:
Lutsenko lab group picture at the department retreat.